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Particularly, as in DIM-5, manavsakti.com these two enzymes depend on residues carboxy-terminal to the SET area for the formation of lysine channel, but they do so by packing of an α helix, somewhat than a steel heart, onto the energetic website. Collectively, the crystallographic studies of SET7/9 and DIM-5 certain to histone H3 peptides have provided a framework for understanding the histone lysine specificity of various SET-domain enzymes.

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