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The concomitant administration of the protease inhibitor ritonavir substantially increases serum concentrations of sildenafil (11-fold increase in AUC). If VIAGRA is prescribed to patients taking ritonavir, caution should be used. Data from subjects exposed to high systemic levels of sildenafil are limited. Decreased blood pressure, syncope, and prolonged erection were reported in some healthy volunteers exposed to high doses of sildenafil (200–800 mg). Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). 25mg is slightly less effective than 50mg and 100mg, but has the lowest risk of side effects and interactions with other medications.

The major circulating metabolite results from N-demethylation of sildenafil. This metabolite has a phosphodiesterase selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% that of the parent drug. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil. The N-desmethyl metabolite is further metabolised, with a terminal half-life of approximately 4 h. When sildenafil is taken with food, the rate of absorption is reduced with a mean delay in tmax of 60 minutes and a mean reduction in Cmax of 29%. In cases of overdose, standard supportive measures should be adopted as required.

Other treatments for ED include topical applications, injections into the penis, surgical devices, penis pumps, and counselling. Other oral ED drugs work in a similar way, with similar side effects. Viagra was the first drug in this class to become widely prescribed.

You can take Sildenafil, an erectile dysfunction medication, every day, up to the maximum recommended dosage of 100mg. Provided you have no pre-existing health issues, and you’re not taking any other ED medications alongside Sildenafil, it is perfectly safe to take several days in a row (or even every day). Spedra tablets treat&nbsp