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See "Dosage adjustments" just above for details about when a lower dose might be prescribed. Physicians should inform patients not to take VIAGRA with other PDE5 inhibitors including REVATIO or other pulmonary arterial hypertension (PAH) treatments containing sildenafil. Sildenafil is also marketed as REVATIO for the treatment of PAH. The safety and efficacy of VIAGRA with other PDE5 inhibitors, including REVATIO, have not been studied [see Warnings and Precautions (5.7)]. Physicians should warn patients that prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of VIAGRA.

VIAGRA is supplied as blue, film-coated, rounded-diamond-shaped tablets containing sildenafil citrate equivalent to 25 mg, 50 mg, or 100 mg of sildenafil. Tablets are debossed with PFIZER on one side and VGR25, VGR50 or VGR100 on the other to indicate the dosage strengths. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. Sildenafil is a phosphodiesterase type 5 (PDE-5) inhibitor. It blocks the action of the enzyme PDE-5, which destroys cyclic guanosine monophosphate (cGMP). An increase in cGMP levels leads to relaxation of the smooth muscles in the penis and increased blood flow, which contributes to an erection.

After taking a dose of Viagra, the drug’s level in your body will gradually decrease over a period of a few hours. You’ll have low levels of the drug in your body after about 4 hours. (And at this point, the drug won’t be working any longer.) But it can actually take about 24 hours for Viagra to be completely removed from your body. Even though Viagra keeps working in your body for several hours, your erection shouldn’t last this long. In fact, in rare cases, Viagra can cause priapism (a long-lasting and sometimes painful erection). Remember, you should not change your dosage of Viagra 25 mg without your doctor’s recommendation.

Two clinical studies were specifically designed to assess the time window after dosing during which sildenafil could produce an erection in response to sexual stimulation. In a separate RigiScan study, sildenafil was still able to produce an erection in response to sexual stimulation 4-5 hours post-dose. Physicians should advise patients to stop use of all PDE5 inhibitors, including VIAGRA, and seek medical attention in the event of a sudden loss of vision in one or both eyes. Physicians should discuss with patients the increased risk of NAION in individuals who have already experienced NAION in one eye. Sold under the brand name Addyi, Flibanserin claims to increase sexual arousal by altering the chemicals in the brain. In the US, the drug - which started as a treatment for depression - is approved to treat low sexual desire in women before menopause.

However, you can safely take up to 100mg of Sildenafil in any 24hr period. You can take up to 100mg of Sildenafil every day, provided you experience no side effects. Due to the fact that Sildenafil is a PDE5 inhibitor, it causes blood vessels to expand and relax. For this reason, it was originally developed as a drug for cardiac conditions.

Co-administration of saquinavir, a strong CYP3A4 inhibitor, resulted in 140% and 210% increases in sildenafil Cmax and AUC, respectively. Stronger CYP3A4 inhibitors such as ketoconazole or itraconazole could be expected to have greater effects than seen with saquinavir. Generic Viagra (Sildenafil) is a medication that is used to treat erectile dysfunction in men. It works by increasing blood flow in the penis, which helps to achieve and maintain an erection. Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss.

This can cause Viagra to build up inside your body, which may increase your risk of side effects from the drug. If you’re thinking of taking illegal drugs with Viagra, talk with your doctor about whether this is safe for you to do. If you take a drug for high blood pressure, your doctor might prescribe a dose of Viagra for you that’s lower than the typical dose. Before taking Viagra, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. A special MedGuide will be given to you by the pharmacist with each new prescription and refill. Lauren Evoy Davis is a health journalist with expertise in cancer and other chronic conditions. She holds a master’s degree in journalism from American University and a bachelor’s degree in English from Elon University. Her work has been published by the American Society of Clinical Oncology, National Council on Aging, HelpGuide WebMD, Everyday Health and Verizon.

Remember to only take Viagra or Viagra Connect as your clinician advises. If you have any questions while you're taking it, just log into your account and send us a message. This has definitely made a difference to my life and with my treatment I am able to be more like my younger self, a heartfelt...

That is why you must discuss it with your doctor before you start Viagra. The drug is capable of many drug-drug interactions causing unpleasant side effects or reducing the potency of other drugs you take. However, psychological dependence may be seen in some people. It is therefore advised to take it only as directed and in recommended doses. Viagra typically starts to work within 30 minutes to 1 hour after ingestion.

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Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of sildenafil. Similar values for pharmacokinetic parameters were seen in normal volunteers and in the patient population, using a population pharmacokinetic approach. In the second study, a single oral dose of VIAGRA 50 mg or matching placebo was administered in a 2-period crossover design to 20 generally healthy males with BPH. Following at least 14 consecutive days of doxazosin, VIAGRA 50 mg or matching placebo was administered simultaneously with doxazosin 4 mg (17 subjects) or with doxazosin 8 mg (3 subjects). In the first study, a single oral dose of VIAGRA 100 mg or matching placebo was administered in a 2-period crossover design to 4 generally healthy males with benign prostatic hyperplasia (BPH).

It should be kept in a tightly sealed container away from light. Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms. When you get Viagra from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This date is typically 1 year from the date they dispensed the medication. And keep in mind that sexual problems can be related to reduced sexual desire and arousal.

But your doctor might prescribe a lower starting dosage of 25 mg depending on several factors. A review of population subgroups demonstrated efficacy regardless of baseline severity, etiology, race and age. Sildenafil at steady state, at a dose not approved for the treatment of erectile dysfunction (80 mg t.i.d.) resulted in a 50% increase in AUC and a 42% increase in Cmax of bosentan (125 mg b.i.d.). The most common adverse reactions reported in clinical trials (≥ 2%) are headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness, and rash. VIAGRA has systemic vasodilatory properties and may further lower blood pressure in patients taking anti-hypertensive medications.

The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see Dosage and Administration (2.5) and Clinical Pharmacology (12.3)]. Co-administration of ritonavir, a strong CYP3A4 inhibitor, greatly increased the systemic exposure of sildenafil (11-fold increase in AUC). It is therefore recommended not to exceed a maximum single dose of 25 mg of VIAGRA in a 48 hour period [see Dosage and Administration (2.4), Warnings and Precautions (5.6), Clinical Pharmacology (12.3)]. Use caution when co-administering alpha-blockers with VIAGRA because of potential additive blood pressure-lowering effects. Prolonged erection greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of VIAGRA.

Your clinician will want to find the lowest dose of the drug that does the job. This is to help keep the likelihood of side effects as low as possible. Your sildenafil dosage may be increased to 100mg if the lower dosage has not had the desired effect. Viagra (sildenafil) is a medication for erectile dysfunction that can help you to get and keep an erection. It works by relaxing your blood vessels and increasing the blood flow to your penis. Sildenafil is a standard &amp