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Although this effect is minor and was of no clinical significance in this study, it should be considered when co-administering these medicinal products. Tadalafil 10 and 20 mg is intended for use prior to anticipated sexual activity and it is not recommended for continuous daily use. Avoid taking grapefruit, or grapefruit juice as they may interact with your medication and increase the risk of side-effects.

The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications. If Cialis is used with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks. Tadalafil blocks the activity of an enzyme called PDE5 (which normally causes erections to subside) and helps blood vessels in the penis to relax and open up.

However, as with any pharmaceutical product under development, there are substantial risks and uncertainties in the process of development, commercialization, and regulatory review. There is no guarantee that the product will receive additional regulatory approvals. There is also no guarantee that the product will continue to be commercially successful. For further discussion of these and other risks and uncertainties, see Lilly's filings with the&nbsp